EXM - Next-Generation Perinatal-Derived Extracellular Matrix
Naturally sourced human tissue in its most natural, original state, just as nature intended.
What is EXM – Extracellular Matrix?
EXM is a next-generation perinatal-derived extracellular matrix (ECM) product, composed of naturally sourced human tissue obtained from the placenta and umbilical cord following healthy, full-term cesarean births. These tissues are not lab-expanded or cloned — meaning they are in their most natural, original state, just as nature intended.
Unlike many products that rely on expanded or manipulated cells, EXM is composed of minimally manipulated human cellular and tissue-based products (HCT/Ps) that retain the natural cellular signaling environment found in the postnatal tissues that support human life.
What's Inside EXM?
Mesenchymal Stem Cells (MSCs)
Naturally occurring, non-expanded stem cells that support regeneration
Progenitor Cells
Early descendants of stem cells with specialized functions
Exosomes
Tiny extracellular vesicles rich in signaling molecules
Growth Factors & Cytokines
Vital for cell communication and tissue regeneration
Perinatal Platelet-Rich Plasma (PRP)
A nutrient-dense matrix of biologically active factors
These components work together to support a healthy cellular microenvironment, much like a coral reef ecosystem—diverse, balanced, and naturally regenerative.
📚 Learn more about MSCs: NIH article
📚 More on progenitor cells: Technology Networks
Sourced from Healthy, Qualified Donors

Healthy Utah Mothers
Known for clean lifestyles
Extensive Screening
Medical and lifestyle assessment
100% Chain of Custody
Collected by trained specialists
EXM is derived from human placental and umbilical tissues donated by healthy mothers in Utah, known for clean lifestyles and low environmental exposure.
Donors go through extensive medical and lifestyle screening, including bloodborne pathogen testing, hereditary and environmental risk assessment, full family medical history evaluation, and toxicology screening (alcohol, drugs, tobacco, vaping, medications).
All tissue is collected under a 100% Chain of Custody protocol by trained recovery specialists within minutes after birth. Testing is conducted by CLIA-certified laboratories compliant with FDA, CMS, CAP, and AABB standards.
Manufactured in the USA – FDA Compliant
FDA-Registered Laboratory
Over 20 years of regulatory compliance and six successful FDA audits
Good Laboratory Practices
Following strict GLP protocols for consistent quality
Made in USA
Supporting American medical innovation and quality standards
The EXM product is produced in an FDA-registered and AATB-accredited laboratory with over 20 years of regulatory compliance and six successful FDA audits.
The product is classified as a Section 361 HCT/P, regulated under 21 CFR Part 1271, Public Health Service Act Section 361, and Good Laboratory Practices (GLP).
Important Note: This product is not FDA-approved and is not intended to diagnose, treat, cure, or prevent any disease or condition. It is classified as an HCT/P for homologous use under current federal regulations. This information is provided for educational purposes only.
Unmatched Testing & Safety Standards

Viral & Bacterial Screening
Comprehensive testing for HIV, Hepatitis, HTLV, CMV, Syphilis, and more

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Nucleic Acid Testing
Early detection of potential pathogens

14-Day Quarantine
Ensuring sterility and viability

Immune Reaction Prevention
Safeguards against Graft-Versus-Host Disease
To ensure product safety and prevent immune reactions such as Graft-Versus-Host Disease, EXM undergoes comprehensive testing including viral and bacterial screening for HIV 1/2, Hepatitis B & C, HTLV I/II, CMV, RPR (Syphilis), and WNV NAT.
The product also undergoes Nucleic Acid Testing (NAT) for early detection of pathogens and a 14-day Quarantine Testing period to ensure sterility and viability.
Cryopreserved with Care

Natural Cryoprotectant
Derived from the tissue's own environment
Cell Viability
Maintains structural integrity
Exceptional Bioavailability
Superior to synthetic preservation
EXM is cryopreserved using a natural cryoprotectant derived from the tissue's own environment. This helps maintain cell viability and structural integrity at the time of use, providing exceptional bioavailability compared to products preserved with synthetic agents.
Why EXM is Different
The Complete Cellular Matrix
While most products focus on a single tissue source (like just umbilical cord or just exosomes), EXM combines multiple postnatal tissues—creating a complete and synergistic cellular matrix that mirrors the natural healing environment of the womb.
This multi-tissue approach is designed to support:
  • Reduced cellular death (apoptosis)
  • Longer cell survival
  • Optimized signaling between cell types
Think of it like using the entire coral reef rather than a single fish—preserving the full biological environment that supports life.
The Coral Reef Analogy
Just as a coral reef represents a complex, interconnected ecosystem where countless organisms work together in harmony, EXM provides a complete cellular matrix where multiple components interact synergistically. This natural approach preserves the biological complexity that makes regenerative processes so effective.
The Science Behind EXM
Cellular Composition
EXM contains naturally occurring, non-expanded MSCs, progenitor cells, and exosomes that work together to create a complete biological matrix.
Cell Signaling
The growth factors and cytokines in EXM facilitate vital cell-to-cell communication, supporting the body's natural processes.
Synergistic Action
Multiple tissue sources create a comprehensive environment that mirrors the natural healing conditions found in perinatal tissues.
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Safety Profile
Rigorous testing and careful preservation ensure both efficacy and safety for homologous use applications.
Comprehensive Testing Protocol
EXM: Nature's Regenerative Solution
What makes EXM different from other products?
While most products focus on a single tissue source (like just umbilical cord or just exosomes), EXM combines multiple postnatal tissues—creating a complete and synergistic cellular matrix that mirrors the natural healing environment of the womb.
How is EXM sourced?
EXM is derived from human placental and umbilical tissues donated by healthy mothers in Utah, known for clean lifestyles and low environmental exposure. Donors go through extensive medical and lifestyle screening, including bloodborne pathogen testing, hereditary and environmental risk assessment, full family medical history evaluation, and toxicology screening.
Is EXM FDA-approved?
This product is not FDA-approved and is not intended to diagnose, treat, cure, or prevent any disease or condition. It is classified as an HCT/P for homologous use under current federal regulations. The product is produced in an FDA-registered and AATB-accredited laboratory with over 20 years of regulatory compliance and six successful FDA audits.
What components are in EXM?
EXM includes Mesenchymal Stem Cells (MSCs), Progenitor Cells, Exosomes, Growth Factors & Cytokines, and Perinatal Platelet-Rich Plasma (PRP). These components work together to support a healthy cellular microenvironment.
If you're considering regenerative biologics, EXM offers a unique, science-backed, and FDA-compliant option that honors nature, safety, and quality.

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RRG-proteomics (1).pdf

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RRG EXM COA Insert Samples.PDF

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